Validated spectrophotometric methods for determination of Alendronate sodium in tablets through nucleophilic aromatic substitution reactions

Validated spectrophotometric methods for determination of Alendronate sodium in tablets through nucleophilic aromatic substitution reactions

BACKGROUND Alendronate (ALD) is a member of the bisphosphonate family which is used for the treatment of osteoporosis, bone metastasis, Paget's disease, hypocalcaemia associated with malignancy and other conditions that feature bone fragility. ALD is a non-chromophoric compound so its determination by conventional spectrophotometric methods is not possible. So two derivatization reactions were ...

Modern Nucleophilic Aromatic Substitution

Validated Spectrophotometric Methods for the Determination of Cefuroxime Axetil in Bulk Drug and Tablets

Two simple spectrophotometric methods have been developed for the determination of Cefuroxime Axetil in bulk drug and its tablet formulation. Method I is a simple UV spectrophotometric method. In this method the simple UV spectrum of Cefuroxime Axetil in 0.1 N HCl was obtained which exhibits absorption maxima (λ max) at 281 nm. Calibration curve was prepared by plotting the absorbance vs. conce...

Spectrophotometric Methods for Estimation of Diclofenac Sodium in Tablets

Diclofenac sodium or Sodium-2-[(2, 6-dichlorophenyl) amino] phenyl] acetate, is widely used as non-steroidal antiinflammatory agent in therapeutics, it inhibits the cyclooxygenase enzyme1. Various spectrophotometric2-11, chromatographic12-18, colorimetric19-20 and flourimetric21-23 methods have been developed for quantification of diclofenac sodium. Extensive literature survey revealed that a v...

Spectrophotometric methods for the determination of prazosin hydrochloride in tablets.

Four simple and sensitive methods for the assay of prazosin hydrochloride (PRH) are developed. These methods are based on the formation of coloured species by treating it either with excess N-bromosuccinimide (NBS) and determining the unconsumed NBS with p-N-methyl aminophenol sulphate (metol)-sulphanilamide (SA) reagent (method A, lambda(max) 520 nm): with 3-methyl-2-benzothiazolinone hydrazon...